Introduction: Involuntary weight loss is a nonspecific sign encountered as a reason for hospitalization in abo-ut 5% of patients admitted to internal medicine depart-ments.

Methods: Patient aged 58 years, hypertensive, known with multiple complications diabetes, with 1 and 3 foot right amputation, is presented for weight loss (8 kg), dysphagia and physical asthenia, symptomato-logy that started 2 months prior to admission ( after finger amputation) and progressively accentuated. Clinical examination revealed pale, dehydrated scars, post-rubbing scars fingers 1 and 3 legs, non-palpable superficial lymph node, MV present bilateral, no ralli-es, SaO2=94% spontaneous, TA =130/70 mmHg, AV =100 bpm, systolic bloating in the mitral and aortic outbreaks, pulse absent in the right popliteal artery, abdomen supple, spontaneously painless and palpation, liver with dph=14 cm.

Results: Biologically, severe anemia, non-specific infla-mmatory syndrome, nitrate retention syndrome, hypo-natremia, hyperglycemia, hepatic cytolysis syndrome, and cholestasis syndrome. Electrocardiogram diffuse ischemic changes were observed. Cardio-pulmonary radiographs showed increased global cord with elonga-tion of the left inferior arch and discrete diffuse stasis. Colonoscopy targeted an angiodisplazic lesion 80 cm from OA. The CT examination revealed a small bila-teral pleural effusion, mediastinal and hileous adeno-pathies, hepatomegaly, cirrhosis liver. Echocardiogra-phy revealed severe mitral regurgitation, moderate-severe aortic regurgitation and multiple vegetation in mitral and aortic valves.

Conclusions: Indiscriminate loss of weight is an alarm signal and requires complex investigations to establish the cause with certainty.