EDITORIAL

1. Dissociation between Animal and Clinical Studies. Where Do We Go Wrong?
   Alina Scridonhttps://doi.org/10.47803/rjc.2021.31.3.497

REVIEW

1. Tissue Engineering Heart Valves – a Review of More than Two Decades into Preclinical and Clinical Testing for Obtaining the Next Generation of Heart Valve Substitutes
   Dan Simionescu, Marius Mihai Harpa, Agneta Simionescu, Codrut Oprita, Ionela Movileanuhttps://doi.org/10.47803/rjc.2021.31.3.501
2. Metabolic Memory in Diabetes – Mechanistic Insights and the Impact of Cardiovascular Medication
   Raluca Sosdean, Loredana N. Ionica, Adrian P. Merce, Danina M. Muntean, Adrian Sturzahttps://doi.org/10.47803/rjc.2021.31.3.511
3. NLRP3 Inflammasome in Cardiovascular Disease: David`s Stone against Goliath?
   Serban Balanescu, Elena Barbu, Camelia Georgescu, Andreea Catarina Popescuhttps://doi.org/10.47803/rjc.2021.31.3.517

ORIGINAL ARTICLE

1. Correlation between Heart Rate Variability and Claustrum Stimulation – Hypothesis, Experimental
   Studies and Future Perspectives
   Bogdan Pavel, Mihaela Roxana Popescu, Carmen-Denise-Mihaela Zahiu, Patricia Demetria Popovici, Diana-Andreea Ilie, Madalina Gherghe, Leon Zagrean, Ana-Maria Zagreanhttps://doi.org/10.47803/rjc.2021.31.3.529
2. The Investigation of Combined Na+/Ca2+ Exchanger and the L-type Ca2+- Channel Inhibition in Langendorff-Perfused Isolated Guinea Pig Hearts
   János Prorok, Annamária Veisbart, Dóra Lipka, Norbert Josthttps://doi.org/10.47803/rjc.2021.31.3.537
3. Inflammation and Hypoxia Negatively Impact the Survival and Immunosuppressive Properties of
   Mesenchymal Stromal Cells In Vitro
   Carmen Alexandra Neculachi, Livia Ioana Leti, Alexandrina Burlacu, Mihai Bogdan Predahttps://doi.org/10.47803/rjc.2021.31.3.547
4. Developing the Tissue Engineered Heart Valve – a Descriptive Hemodynamic and Ultrasound in Vitro
   Characterization Study of Heart Valves in a Bioreactor
   Ionela Movileanu, Dan Octavian Nistor, Leslie Sierad, Klara Brinzaniuc, Codrut Oprita, Marius Mihai Harpa, Terezia Preda, Ovidiu Cotoi, Hussam AL Hussein, Hamida AL Hussein, Alexandru Chertes, Horatiu Suciu, Agneta Simionescu, Dan Simionescuhttps://doi.org/10.47803/rjc.2021.31.3.555
5. In Silico Analysis of Novel Titin Non-Synonymous Missense Variants Detected by Targeted Next-Generation Sequencing in a Cohort of Romanian Index Patients with Hypertrophic Cardiomyopathy
   Miruna Mihaela Micheu, Nicoleta Oprescu, Nicoleta-Monica Popa-Foteahttps://doi.org/10.47803/rjc.2021.31.3.565
6. Studying the Innate Immune Response to Myocardial Infarction in a Highly Efficient Experimental Animal Model
   Razvan Gheorghita Mares, Doina Manu, Istvan Adorjan Szabo, Mihaela Elena Tomut, Gabriela Pintican, Bogdan Cordos, Gabriel Jakobssons, Minodora Dobreanu, Ovidiu Simion Cotoi, Alexandru Schiopuhttps://doi.org/10.47803/rjc.2021.31.3.573
7. Chronic Exposure to High Doses of Bisphenol A Exhibits Significant Atrial Proarrhythmic Effects in Healthy Adult Rats
   Vasile Bogdan Halatiu, Alkora Ioana Balan, Dan Alexandru Cozac, Remus Bobarnac, Marcel Perian, Razvan Constantin Serban, Alina Scridonhttps://doi.org/10.47803/rjc.2021.31.3.587
8. Role of Preexisting Proarrhythmic Atrial Remodeling in Post-Coronary Artery Bypass Grafting Atrial Fibrillation
   Alkora Ioana Balan, Irina Pintilie, Cristina Somkereki, Marcel Perian, Laura Chinezu, Claudia Banescu, Razvan Constantin Serban, Alina Scridonhttps://doi.org/10.47803/rjc.2021.31.3.597
9. Cardiac Contractility Modulation Therapy for Heart Failure – First Romanian Experience
   Diana Tint, Sorin Micuhttps://doi.org/10.47803/rjc.2021.31.3.609
10. The Workload of the Interventional Cardiology Centers from Romania: a 2020 Overview and 2014-2020 Trends
    Lucian M. Predescu, Cristian A. Udroiuhttps://doi.org/10.47803/rjc.2021.31.3.615

CASE PRESENTATION

1. An Uncommon Congenital Abnormality Discovered Using Multimodality Cardiac Imaging in an Elder
   Hospitalized For Decompensated Heart Failure
   Alexandra-Ioana Hriban, Daniela Crisu, Manuela Ursaru, Laurentiu Sorodoc, Catalina Liontehttps://doi.org/10.47803/rjc.2021.31.3.627
2. A Case of Enterococcus Spp. Endocarditis in a Seemingly Cured Hemorrhoidal Disease. Case Report
   Laura Alexandra Mitrea, Ruxandra Dragoi Antunes Guerra Galrinho, Stefania Lucia Magda, Diana Mihalcea, Dragos Vinereanuhttps://doi.org/10.47803/rjc.2021.31.3.633

EDITORIAL

1. IN MEMORIAM – Dr. Ernst Schneider (1940-2021)
   Marian Croitoru

GUIDELINES

1. 2020 ESC Guidelines for the Management of Atrial Fibrillation

INSTRUCTIONS FOR AUTHORS

1. Instructions for authors