Introduction: It has been demonstrated that the central aortic ratio of the diastolic and systolic pressuretime index, also designated as subendocardial viability ratio (SEVR), is strongly related to subendocardial blood supply and could estimate the risk of myocardial ischemia. This study aimed to evaluate the relationship between the cardiovascular risk profile and SEVR in hypertensive patients without ischemic heart disease. Methods: Our study included 78 hypertensive patients without ischemic coronary disease (mean aged 57.8 ± 2.1 years, 69% males), divided in two subgroups according SEVR values (cut-off 0.45). All patients were assessed for cardiovascular risk factors, left ventricle mass index (LVMI), microalbuminuria, and creatinine clearance. SEVR, central aortic pressure, pulse wave velocity were determined using Arteriograph device. Results: Hypertensive patients with low SEVR values were older (65.4 ± 1.09 vs 51.6 ± 2.3 years), with higher values of LDL-cholesterol (237.7 ± 4.3 vs 178 ± 2.1 mg %) and glucose (103 ± 1.1 vs 89 ± 2.3 mg%). Signifi cant lower values of SEVR were observed in smokers (0.34) and obese males (0.32), p < 0.05. SEVR were related with LVMI and systolic blood pressure (BP) (ANOVA). SEVR was still independently related to PWV, central aortic pressure, LVMI and plasma glucose after stepwise regression analysis. Our study demonstrated no influence for renal function parameters and diastolic BP (p >0.05). Conclusions: This study demonstrates the practical value of SEVR for detaching the hypertensive subgroup with risk of myocardial ischemia. A full determination of cardiovascular risk profile is also needed because PWV, central aortic pressure, LVMI and plasma glucose are the most reliable parameters for individual evaluation.