Introduction: As almost half of the heart failure patients are those with preserved ejection fraction, we aimed to assess the presence of inflammatory markers at the time of primary diagnosis of ejection fraction heart failure and to compare their values with the proven diagnostic and prognostic parameters (pro-BNP, NT pro-BNP), as well as with the clinical status parameters (exercise capacity and quality of life) at inclusion and aft er 1 year. Methods: 78 patients who had clinical signs of heart failure and primary diagnosis of heart failure with preserved ejection fraction were included in the present study. Inclusion criteria: sinus rhythm, clinical signs and symptoms of heart failure, according to Framingham criteria, FE ≥ 45 %, E/E
´ ≥ 15, pro-BNP >150 pg/ml. All the patients have signed Informed Consent forms. Twelve months aft er patients’ inclusion, inflammatory markers, along with pro-BNP, NT proBNP and clinical status components were reassessed. Pearson’s correlation coefficient and multiple linear regression, and T-test for 2 Independent Means have been used. Results: A moderate correlation between TNF level and pro-BNP and NT pro-BNP, as well as between TNF level and clinical status components, all these correlations being statistically significant (p < 0.001). As the IL6 values concerns, a weak correlation has been seen with NT pro-BNP value at inclusion. One year aft er the inclusion, statistically significant correlations between TNF, pro-BNP and NT pro-BNP remained the same, weaker correlations being recorded between them and clinical status parameters. A moderate, statistically significant correlation has been seen between IL6 and clinical status parameters at one-year follow-up. Conclusions: Considering the high number of comorbidities in the patients suffering from heart failure with preserved ejection fraction, in which a proinflammatory status is also associated, the possibility to study inhibitor therapy upon inflammatory activity should not be neglected for these patients. In conclusion, inflammatory markers are correlated with prognostic markers already proven in heart failure and clinical status parameters; they may be predictors for heart failure evolution.