Objective: We present the case of a 77-year-old obese female, admitted for edema of the right inferior limb + inflammatory phenomena.

Methods: We present the case of a 77-year-old obese female, admitted for edema of the right inferior limb + inflammatory phenomena. Venous eco Doppler visua-lizes GSV dilated with signs of venous thrombosis. An anticoagulant treatment with UFH is instituted. After 48 hours the patient has haematuria and metrorrhagia. Abdominopelvic CT scan elevates suspicion of uterine neoplasm with bladder extension. Because of the per-sistence of haemorrhagic phenomena, we changed the anticoagulant with HGMM. The haematuria persisted– we stop the anticoagulant temporarily, until the stop of the active bleeding. At venous Doppler reexamina-tion – no venous thrombosis, only spontaneous con-trast. Uterine biopsy is performed at gynecology. After biopsy, the patient experiences syncope, dyspnea, ta-chycardia. The echocardiography shows signs of APE. It is transferred to cardiology where the anticoagulant treatment with UFH is restored.

Results: Cardiological examination is recommended 30 days after discharge for re-evaluation; earlier in case of new symptoms; gynecological and oncological con-sultation in order to establish definite diagnosis and therapy of uterine neoplasia

Conclusions: Lipsa