Introduction: Antiphospholipid syndrome (APLS) is a clinical entity associated with venous or arterial thrombotic events. However, the predictors for occurrence of deep vein thrombosis in patients with APLS and systemic lupus erythematosus (SLE) are incompletely evaluated. Objectives: The aim of this study was to evaluate the impact of systemic inflammation in patients with APLS secondary to SLE. Methods: In 47 patients with APLS secondary to SLE, we performed the evaluation of traditional risk factors associated with DVT. We assessed the inflammation parameters [erythrocyte sedimentation rate (ESR), fibrinogen and C-reactive protein (CRP) levels]. We divided the study group in two subgroups: A – patients with DVT; and B – patients without DVT. Results: In our study group 18 (38.3%) patients were diagnosed with DVT. Mean age, sex distribution, smoking rate, obesity parameters (body mass index, abdominal circumference, waist-to-hip ratio) were similar in both subgroups. ESR (29.76 ± 4.71 vs 19.71 ± 2.63, p = 0.05), fi brinogen (375.88 ± 18.26 vs 326.71 ± 12.45, p = 0.02), CRP (12.09 ± 3.68 vs 3.35 ± 0.70, p = 0.006) were found to have higher values in patients with DVT. However, in multivariate analysis, only CRP was independently associated with DVT (p = 0.03). Conclusions: Inflammation seems to be one of the pathogenic pathways in patients with APLS secondary to SLE and DVT. Further studies are required in order to have valid conclusions.