Introduction: The study of the presence and characteristics of concomitant chronic peripheral and carotid arterial disease in patients with coronary artery disease. Methods: We performed a retrospective study on 102 patients (71 men, 36 women, mean age 65 years), with significant stenosis on coronary angiography. The patients were divided into two groups: group I – with mono- and bivascular disease, and group II – with trivascular and diffuse coronary artery disease. In all patients we evaluated the peripheral arterial vascular bed and the carotid arteries (clinical exam, CW Doppler, duplex scan, arteriography). For data analysis chi-square test was used (significant p < 0.05). Results: In 9.25% of patients (8.33% vs 10.16%) we found symptomatic peripheral arterial disease. There were no significant differences between the two groups regarding the Fontaine staging (p = 0.1967), the localization (proximal or distal, p = 0.2357) of arterial disease and the prevalence of significant carotid stenosis (p = 0.6783). Conclusions: There is no significant correlation between the severity of coronary and peripheral arterial disease. In patients with coronary artery disease, confirmed invasively, it is necessary to assess the peripheral arterial vascular bed routinely.