Introduction: Dilated cardiomyopathy represents a public health problem and a frequent cause of addres-sing to the emergency room through decompensation episodes. Associated comorbidities are a major de-terminant of prognosis in dilatation cardiomyopathy. Although major therapeutic advances have been made, cardiac transplantation remains the main treatment in advanced forms of dilatation cardiomyopathy.

Methods: We conducted a prospective study on 160 patients admitted to the Third Medical Clinic of the Emergency County Clinical Hospital „Sf. Spiridon“ in Iași between 1 January 2018 and 31 May 2019. Demo-graphics, the presence of cardiovascular risk factors, clinical symptoms, associated co-morbidities, and the impact of drug therapy on disease progression have been analyzed and correlated. The monitoring of the study group included sampling of bioumoral tests, elec-trocardiogram, transthoracic echocardiography and/or other individualized investigations.

Results: In the studied group, 80% of the hospitalized patients had the signs and symptoms of cardiac decom-pensation, being in the NYHA class III and/or IV. There was a higher proportion of male gender, predominantly from rural area (53%) and with low level of educati-on. Clinical manifestations were most commonly seen in patients aged between 60 and 70 years. High blood pressure, diabetes mellitus and dissipation were the main associated comorbidities. Absence of the correct drug response is a negative prognostic indicator. In the studied group, tachyarrhythmia, dominated by atrial fibrillation with rapid ventricular rate, were the main precipitating factor of heart failure.

Conclusions: Dilated cardiomyopathy has an impor-tant impact on quality of life, associating multiple com-plications and high mortality. Patients’ social and eco-nomic conditions play an important role in the evolu-tion and prognosis of dilatation cardiomyopathy. Most patients usually present in late stages of heart failure requiring a holistic approach.