Introduction: Exercise stress test (ET) is a non-invasive method of diagnosis, evaluation and prediction of the coronary disease. In the context of the overloading of the cardiac catheterization labs and of the high costs of these explorations, ET represents an initial selection method of the patients for coronarography. The current study evaluates some clinic and paraclinic parameters at the patient with positive exercise stress test vs. false positive exercise stress test. Methods: We designed a retrospective study based on the ET and medical records data of 102 patients without anterior coronary disease diagnosis that have done ET in a period of 12 months at the Cardiovascular Diseases Institute Iași and who, at coronarography, had no signifi cant coronary lesions, their ET being considered false positive. The control group consisted of 102 patients with positive ET and significant coronary lesions, selected to match by sex and age the study group. For both groups, we have evaluated demographic parameters, cardiovascular risk factors, echocardiographic parameters, the treatment, the resting ECG and ET parameters. Results: We have studied 102 patients with false positive ET (61.2 years old, 55.88% women). Comparing to the control group, the study group consisted in less diabetics (15% vs 50%, p = 0.02), smokers (p = 0.002), obese (65% vs 88%, p = 0.02) and dyslipidemic patients (p = 0.009), but more hypertensives (74% vs 40%, p = 0.02). Patients with no significant coronary lesions have more frequent echocardiographic changes suggestive for left ventricle hypertrophy (77% vs 40%, p = 0.04) and regarding the ET, they present less frequent angina (50% vs 80%, p = 0.02), exaggerated hypertensive response (3% vs 36%, p = 0.02) and ST depression ≥ 2 mm (40% vs 65%, p = 0.01). The remission period of the ST depression is oft en ≤ 4 minutes (56% vs 40%, p = 0.02) and the functional capacity is beter at the patients with false positive ET (p = 0.007). Conclusions: The predictors for the false positive ET are: hypertension, a SCORE risk ≤ 4%, the echocardiographic changes suggestive for left ventricle hypertrophy, the absence of the angina, ST depression ≤ 1.9 mm with remission in ≤ 4 minutes. The functional capacity of the patients with false positive ET is oft en normal comparing to the reduced functional capacity of the patients with coronary lesions. At the patients with false positive ET it is recommended to complete the investigations with other imagistic explorations, such as coroCT and to evaluate the other possible causes of the thoracic pain.