Assessment of the prognosis of complications in congenital aortopathies in children

Scope: Early diagnosis, timely therapy and the study of predictive factors are essential principles of importance applied in optimizing the prevention of expansive complications in congenital aortopathies (CAo) in children.

Methods: Analytical follow-up study. 91 children with CAo were included, of which: girls=33 (36,3%), boys=58 (63,7%), age range-10-18 years. A complete echocardiography was performed including the eva-luation of 6 aortic diameters (annular level, Valsalva sinus, sinotubular junction, ascending aorta, aortic arch, descending aorta) and additional clinical-para-clinical data specific to the researched pathology were analyzed. Participants were stratified according to Z scores of aortic diameters in 2 groups, group I – 52 chil-dren with unfavorable dynamics (two and more dilated diameters); group II – 39 children with favorable evolution (without dilation or only a single dilated segment). Discriminatory statistical analysis was used to highli-ght predictive factors.

Results: There were 6 factors that varied significantly in both subgroups of children, namely: decreased tolerance to physical exertion (group I – 43 (82,7%) vs group II – 37 (94,9%; p<0,05), dilation of the aortic dia-meter at the level of the aortic valve (lot I – 19,37 ± 0,61 vs lot II-16,436 ± 0,72 mm; p<0,05), dilation of the aortic diameter at the level of the sinotubular juncti-on (lot I – 20,53 ± 0,5 mm vs lot II-17,82 ± 0,9 mm; p<005), diameter dilation at ascending aortic level, (lot I – 26,6 ± 0,89 mm vs lot I – 22,692 ± 0,8 mm; p<0,05, aortic dilation at the level of aortic arch (lot I – 13,79 ± 0,3 mm vs lot II – 14,56 ± 0,2 mm; p<0,05) and changes in diameter in the left ventricle (group I – in 5 cases (12,8%) and group II – absent; p<0,05).

Conclusions: To predict the development of complications such as dissection, aneurysm, aortic rupture, the following factors were highlighted: decreased tolerance to physical exertion, dilation of the aortic diameter at the level of the aortic valve, dilation of the aortic diameter at the level of the sinotubular junction, of the ascending aorta, dilation of the aorta at the level of the aortic arch, changes in diameter at the level of the left ventricle. The discriminant analysis allows the progno-sis in children with CAo with changes in aortic diameter in 78,85% of cases, and in those without changes in aortic diameter in 82,05% of cases. Keywords. CAo, children, complications, prognosis.

ISSN
ISSN – online: 2734 – 6382
ISSN-L 1220-658X
ISSN – print: 1220-658X
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CNCSIS B+
CODE: 379
CME Credits: 10 (Romanian College of Physicians)
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